METHOD
A prospective, singlearm multicentre study was carried out to assess GI tolerance and compliance to a new formula, Peptamen HN PHGG®. Participants were under the care of a Dietitian and recruited from two NHS settings. Participants were adults who were tube fed, receiving >60% of their estimated requirements enterally, experiencing GI discomfort (diarrhoea, constipation, excessive wind or nausea) and able to consent.
RESULTS
21 participants (30–88 years), identified by Dietitians as meeting inclusion criteria, were consented and enrolled; 13 participants had completed the trial at the time of writing.
Primary diagnoses included oesophageal cancer, GI tract surgery, pancreatitis, aspergilloma, EhlersDanlos, and myasthenia gravis. Four participants were fed into the stomach and nine into the jejunum. All patients began the trial due to diarrhoea.
At baseline, 92% (n=12) had a type 6 or 7 stool; one patient had an ileostomy reporting diarrhoea. At the end of the study, 77% (n=10) reported a type 4 or 5 stool, with only 23% (n=3) still reporting type 6 or 7. Average stool frequency decreased from 2.9 to 2.3 per day.
77% (n=10) reported improved tolerance after starting the formula. 92% (n=12) tolerated the prescribed volume; 54% (n=7) tolerated a higher volume compared to their previous feed.
CONCLUSIONS
Tubefeed tolerance remains a challenge. Historically, Dietitians have needed to choose between a semielemental peptidebased feed or a fibre feed. This study shows Peptamen HN PHGG® was well tolerated by most participants, with reductions in undesirable GI symptoms, improvements in stool frequency and type, increased compliance, and high satisfaction levels.
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Acceptability and tolerance study of a high‑protein semi‑elemental feed containing PHGG fibre
- 18/02/2026
This webinar had the focus on the use of fibre supplements' in the nutritional management of patients with acute illness. The speaker, Nirouz Zarroug, discussed the impact of clinical decisions related to patient care.
The use of a PHGG supplement or a nutritionally complete formula containing PHGG as a source of soluble dietary fibre can be helpful to manage paediatric conditions associated with chronic or recurrent gastrointestinal symptoms. Claudio Romano, Socrate Pallio , Ugo Cucinotta , Paola Accorsi & Valeria Dipasquale (2021): Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases, Expert Review of Gastroenterology & Hepatology. DOI: 10.1080/17474124.2021.1884543
Question is part of “Fibre Maze; Influence on Gut Health and GI disorders” webinar. The answer is delivered with Dr Graeme O’Connor RD PhD , Clinical Academic Lead , Great Ormond Street Hospital, UK. To watch the full length of the sessions Fibre Maze: Influence on Gut Health and GI disorders Session 1 click here. & Session 2 click here. & for Q&A session click here. & for PHGG fibre Expert Experience click here. To read and download more on PHGG fibre “Fibres in paediatric functional gastrointestinal disorders. Practical considerations from clinical cases” click here.
This session is part of the webinar 'Fibre Maze – Influence on Gut Health and GI disorders'. In this session Dr. Anna Rybak & Dr Graeme O’Connor answered questions and discussed topics raised by dietitians during the event.
Question is part of “Fibre Maze; Influence on Gut Health and GI disorders” webinar. The answer is delivered with Dr Graeme O’Connor RD PhD , Clinical Academic Lead , Great Ormond Street Hospital, UK. To watch the full length of the sessions Fibre Maze: Influence on Gut Health and GI disorders Session 1 click here. & Session 2 click here. & for Q&A session click here. & for PHGG fibre Expert Experience click here. To read and download more on PHGG fibre “Fibres in paediatric functional gastrointestinal disorders. Practical considerations from clinical cases” click here.
This session is part of the webinar 'Fibre Maze – Influence on Gut Health and GI disorders'. In this session Dr. Graeme discusses the barriers to meet nutrition requirements in an acute clinical setting plus a case study presentation.
This session is part of the webinar 'Fibre Maze – Influence on Gut Health and GI disorders'. In this session Dr. Anna discusses how fibre plays an essential role in maintaining the structure and function of the gut microbiome. Dr Anna Rybak is paediatric gastroenterologist, and she is a co-author of 50 publications, first author of 13 original publications, and a co-author of several book chapters on motility disorders and feeding disorders in children.