Advancing the Management of Cow’s Milk Protein Allergy: Human Milk Oligosaccharides and Immune Development Webinar4 Credits
The first 1,000 days of life are a window of opportunity to set solid foundations for infants’ future health. This period is a time of rapid physiological change and plasticity with significant potential for lasting effects.1 It is also a period of heightened vulnerability.2
Infants are born with a functionally immature intestine3 and a developing gut microbiota4 and immune system5.
Cow’s milk protein allergy is an immune-mediated disease6 associated with an increased gut permeability and altered gut microbiota composition (dysbiosis)7-9 which can disrupt immune system maturation and can result in long-term health consequences10.
Human milk oligosaccharides, a major component of breast milk11, have an important immune-nurturing role.11,12 Breastfeeding is the gold standard for infant nutrition and should always be supported.13
New research is showing that the addition of two structurally identical HMO to infant formula helps to protect them from infections and reduce related antibiotic use14-15. This is likely in part through their effects on the gut microbiome of young infants16.
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Nestlé’s HMO blend positively shapes the gut microbiome and reduces infections in infants with CMPA – Press Release. See the press release here
1. The biology of the first 1,000 days. Taylor & Francis eBooks, 2018 2. Agosti M, et al. Pediatr Med Chir 2017;39(2):157 3. Chin AM, et al. Semin Cell Dev Biol 2017;66:81-93 4. Robertson RC, et al. Trends Microbiol 2019;27(2):131-47 5. Holt PG, Jones CA. Allergy 2000;55:688-97 6. Crittenden RG and Bennett LE. J Am Coll Nutr. 2005;24(6):582S–591S 7. Thompson-Chagoyan OC, et al. Allergy Int Arch Allergy Immunol. 2011;156(3):325–32 8. Azad MB, et al. Clin Exp Allergy. 2015;45(3):632-43 9. Jalonen T. J allergy Clin Immunol.1991;88(5):737-42 10. Tanaka M, Nakayama J.Allergol Int 2017;66(4):515-22 11. Donovan SM and Comstock SS. Ann Nutr Metab 2016;69(Suppl 2):42-51 12. Walsh C, et al. J Funct Foods. 2020;72:104074 13.Koletzko S, et al. J Pediatr Gastroenterol Nutr 2012;55(2):221-9 14. Puccio G, et al. J. Pediatr Gastroenterol Nutr 2017;64(4):624-3126.15. Nowak-Wegrzyn A, et al. Nutrients 2019;11(7):E1447 16. Berger B, et al. mBio 2020;11(2):e03196-19